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Tel: +1 4; Fax: +1 4; E-mail: [email protected] The mechanisms by which neural precursor cells (NPCs) enhance functional recovery from spinal cord injury (SCI) remain unclear.Spinal cord injured rats were transplanted with wild-type mouse NPCs, shiverer NPCs unable to produce myelin, dead NPCs, or media.Most animals also received minocycline, cyclosporine, and perilesional infusion of trophins.Motor function was graded according to the BBB scale.H&E/LFB staining was used to assess gray and white matter, cyst, and lesional tissue.
Animals transplanted with wild-type NPCs showed greatest functional recovery; animals transplanted with shiverer NPCs performed the worst. Shiverer NPCs ensheathed axons but did not produce MBP.These results suggest that remyelination by NPCs is an important contribution to functional recovery following SCI.Shiverer NPCs may prevent remyelination by endogenous cells capable of myelin formation. A dating site that not only understands what it is to be over 50, but also celebrates this exciting chapter of our lives.At Our Time.com, we honor the freedom, wisdom and appreciation for life that only comes with time.
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